Stage 2 of the 2023 Giro d'Italia took place on .

The stage started in Teramo and finished in San Salvo, starting at with an expected finish at (average speed of 43 km/h).

The total distance of the stage was 202.6 km. The stage included 0 categorized climb(s) and 0 intermediate sprint(s), and had a total elevation gain of 2682 m, and a total descent of -2871 m.