Stage 4 of the 2025 Vuelta a Burgos Feminas was a lumpy stage that took place on .

The stage started in Villasana de Mena and finished in Lezana de Mena, starting at with an expected finish at (average speed of 47 km/h).

The total distance of the stage was 9.4 km. The stage included 0 categorized climb(s) and 0 checkpoint(s), and had a total elevation gain of 109 m, and a total descent of -47 m.