Stage 4 of the 2023 Vuelta España Femenina was a hilly stage that took place on .

The stage started in Cuenca and finished in Guadalajara, starting at with an expected finish at (average speed of 38 km/h).

The total distance of the stage was 133.6 km. The stage included 0 categorized climb(s) and 0 intermediate sprint(s), and had a total elevation gain of 1450 m, and a total descent of -1656 m.