Stage 5 of the 2025 Simac Ladies Tour was a flat stage that took place on .

The stage started in Doetinchem and finished in Westendorp, starting at with an expected finish at (average speed of 45 km/h).

The total distance of the stage was 10.3 km. The stage included 0 categorized climb(s) and 0 checkpoint(s), and had a total elevation gain of 0 m, and a total descent of -1 m.